In 2005, Nolan Hayes rushes his wife Abigail to a New Orleans hospital as she is in labor five weeks early. She dies in childbirth and leaves behind a newborn girl, who must be kept in a ventilator for the next two days before she can breathe on her own. As Hurricane Katrina approaches, the hospital is evacuated, and Nolan is left alone with his daughter (whom he names Abigail, after her mother) because the ventilator cannot be transported. In his search for food, Nolan encounters a cook on his way to a nearby hospital unaffected by the hurricane and receives change for the vending machines and some sausage. After a nurse promises to bring back help, the flooding of the basement causes a power outage, prompting Nolan to search for a generator for the ventilator battery. The generator he finds must be hand-cranked every three minutes, and with each charge the battery life gets shorter, making Nolan's every action an increasingly tight race against time.
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